Overview

1998 SIAM Student Prize, presented Toronto 1999
2012 Lee Segel Prize (shared), presented Arizona 2013
EPSRC Leadership Fellow, 2010-2015

EPSRC Healthcare Technology Impact Fellow, 2016-2018

Qualifications

BSc (1st Class) Edinburgh University 1990-1994
MSc Nonlinear Mathematics, Bath University 1994-1995
PhD Engineering Mathematics, Bath University 1997-2000

Career

Defence-related Project Engineer (satellite imaging), SEA Ltd, Beckington Castle, Frome, 1995-1996
Lecturer in Mathematics, Imperial College London, 2000-2005
Senior Lecturer in Mathematics, Imperial College London, 2005-2008
Reader in Mathematics, Imperial College London, 2008-2010
Professor Mathematical Biosciences, EPSRC Leadership Research Fellow 2010

EPSRC Healthcare Technology Impact Fellow 2016-2018

Links

• my homepage

Research group links

• Microbial Evolutionary Ecology

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Research

Research interests

• Mathematical modelling of evolutionary datasets, particularly those relating to antibiotic resistance
• Mathematical analysis of differential-algebraic equations
• Applications of mathematical analysis/computation to evolutionary biology

Research projects

• Understanding viral phage resistance in E.coli populations (with Justin Meyer)
• Using optimisation theory as a basis to model optimal antibiotic use (with Hinrich Schulenberg)
• Using AI to understand clinical definitions of antibiotic resistance (with Emily Wood, Jon Iredell and Pablo Catalan)
• Understanding how death processes are mediated by antibiotics (with Emily Wood)
• Understanding how solution paths of long-range diffusion (integro-differential) equations transition from one Banach space to another (with Robert Laister)
• Understanding how changing the order of antibiotic use impinges rates of resistance evolution (with Emily Wood and Pablo Catalan) 
• Developing novel hardware to interrogate microbes (with Singer Instruments)

Research networks

EPSRC-funded (now finished) Mathematical Models and Experimental Microbial Systems (www.mmems.org)

Research grants

• 2020 EPSRC
  A collaborative hub award to research datasets and mathematical models arising in healthcare
• 2016 EPSRC
  Award to conduct full-time research into datasets on phage and antibiotic resistance
• 2012 EPSRC
  Developing Leaders award (value £315,000)
• 2012 EPSRC
  Creativity @ Home award (value £20,000)
• 2010 EPSRC
  Leadership Fellowship on the application of mathematical modelling to the study of antibiotic resistance evolution (value £1,139,110)
• 2010 EPSRC
  Cross-Disciplinary Enhancement to Leadership Fellowship: funding to take theoretical research into the lab (value £100,000)
• 2009 MRC
  Discipline Hopping Fellowship: Applications of Control Theory to Optimal Antibiotic Deployment (value £110,000)
• 2002 EPSRC
  Funded Two PDRAs on the Invariant Manifolds of Differential-Algebraic Equations (value £123,000)

Links

• EPSRC-funded network: Mathematics and Microbes
• Homepage

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External Engagement and Impact

Awards and distinctions

1998 SIAM Student Prize, presented Toronto 1999
2012 Lee Segel Prize (shared), presented Arizona 2013

2023 Vivli Data Challenge Innovation Prize
EPSRC Leadership Fellowship, 2010-2015

EPSRC Healthcare Technologies Fellowship 2016-2018

Committee/panel activities

Member of EPSRC College, members of several panels for example:

former EPSRC Leadership Fellows Sift and Interview Panels Member in Mathematics, Doctoral Training Centres Sift and Interview Panels Chair in Healthcare Technology, Programme Grant Panel Member in Mathematics, Responsive Mode Grant Panel Member (several)

Reviewer for EPSRC, BBSRC, NSERC (Canada), Portuguese Foundation for Science and Technology (FCT), ETH Zurich Collaborative Highly Interdisciplinary Research Projects and many others...

Advisory Board Member: The Physics of Antimicrobial Resistance (grant# EPSRC EP/T002778/1) 2019-2022

Invited lectures

2008 NESCent Research Meeting, April 7-10, Duke University Campus
2008 Bifurcation Theoretic Computations for 1-d DFTs, June 24th, Imperial College
2008 17th Annual Scottish Computational Mathematics Symposium, September 10th, Heriot-Watt University, Edinburgh
2008 IEEE Seminar, Devry Institute, New Brunswick, New Jersey, US.

2009 PIMS Lecture Series (University of Alberta and UBC, Vancouver), February
2009 Analyse des Systemes et Biometrie, March, Montpellier, France
2009 One-week postgraduate lecture course: Phase Transition Tracking for Classical Density Functional Theory, April, University Carlos III, Madrid
2009 ESA, Special Session on Microbial Evolution in Ecology, June, Albuquerque, New Mexico, US
2009 Epidemiology Seminar Series, Department of Zoology, University of Oxford, October

2010 Optimal control theory & rotating or mixing antibiotics, Yale, Connecticut, US, Jan
2010 Coevolution - Rapid Reciprocal Adaptation and its Genetic Basis, `Phenotypic diversity versus resource supply for GxE and GxGxE interactions in the chemostat,' Kiel, Feb
2010 Centre for Evolutionary Genetics Seminar, September, Kiel University,
2010 Basque Center for Applied Mathematics (BCAM), December, Bilboa, Spain

2011 Centre for Evolutionary Genetics Seminar, Kiel University, September
2011 Maths for Microbes session; Society for General Microbiology, Spring Conference, Harrogate, April
2011 Departmental Seminar, Engineering Mathematics, Bristol University, December
2011 H. Lee Moffitt Cancer Center, IMO seminar, December

2012 Seminar, Harvard Medical School (Kishony Lab), Boston US, February
2012 OEB `Special Seminar' Harvard Systems Biology Seminar, Boston US, February
2012 International Conference of Numerical Analysis and Applied Mathematics, Halkidiki, Greece, September; plenary symposium on the applications of numerical analysis and scientific computation in mathematical biology
2012 Department of Systems Biology, Novo Nordisk Foundation Center for Biosustainability, Copenhagen, December

2013 Colloquium (Optimisation in Biology) ETH Zurich in Basel, January
2013 Cavendish Laboratory Seminar Series, Cambridge, February
2013 Thematic Programme on Mathematical Biology, Lyon, March, plenary talk, mathbio2013.sciencesconf.org/
2013 Departmental Seminar (Mathematical Medicine), Nottingham, October
2013 Agents against Infectious Diseases, plenary talk, University Wurzburg, November

And many others ... 

Workshops/Conferences organised

2006-2009: Imperial organiser of M4 Corridor PG Days in Numerical Analysis with Oxford, Brunel, Reading, Bath and Cardiff

2008 Bifurcation-Theoretic Computations and Classical Density Functional Theory, 24th June, Imperial College, London, approximately 20 attendees

2010 Organised the Mathematics of Microbes: Biophysical Details of the Evolving Cell, April, Imperial College, London, approximately 50 attendees

2013 Quantitative Evolutionary Dynamics (QED): microbes from cells to populations in their natural environments, April, Shaldon near Exeter University, UK, approximately 50 attendees

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Teaching

Modules

2023/24

• BIO2104 - Introduction to Declarative Computer Programming

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Supervision / Group

Postdoctoral researchers

Postgraduate researchers

Alumni

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